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Moderate hypothermia attenuates α<sub>1</sub>-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide(Short communication)

Nurullahoglu-Atalik, KE and Cenker, A (2016) Moderate hypothermia attenuates α<sub>1</sub>-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide(Short communication). Physiology International, 103 (4). pp. 481-486. ISSN 2498-602X

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Abstract

The effects of moderate hypothermia (28 °C) on the response of human varicose spermatic vein to α<sub>1</sub>-adrenoceptor agonist phenylephrine and the role of endothelial nitric oxide (NO) in these effects were studied. Concentration–response curves for phenylephrine (10<sup>−9</sup> to 3 × 10<sup>−4</sup> M) were recorded in rings with and without endothelium at 37 and 28 °C. To further analyze the role of NO, in the response to phenylephrine during hypothermia, the effects of this agonist in the presence of N<sup>G</sup>-nitro-<sc>L</sc>-arginine methyl ester (10<sup>−4</sup> M) were also determined. Under every condition tested, phenylephrine produced a marked, concentration-dependent contraction. Sensitivity of intact veins to the agonist was consistently lower at 28 °C than at 37 °C. There was no significant difference in phenylephrine response at 28 and 37 °C in vessels without endothelium but at 28 °C veins without endothelium showed a higher sensitivity than intact veins to phenylephrine. The sensitivity of veins with and without endothelium to nitroprusside (10<sup>−9</sup> to 3 × 10<sup>−3</sup> M) was significantly decreased during hypothermia, and endothelium removal did not affect the relaxation to this nitrovasodilator. These results suggest that moderate hypothermia decreases the sensitivity of human varicose spermatic vein to phenylephrine probably by increasing the availability of endothelial NO.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: Ágnes Sallai
Date Deposited: 26 Jan 2017 08:53
Last Modified: 31 Dec 2017 00:17
URI: http://real.mtak.hu/id/eprint/46428

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