REAL

Regulation of B cell functions by Toll-like receptors and complement

Kremlitzka, Mariann and Mácsik-Valent, Bernadett and Erdei, Anna (2016) Regulation of B cell functions by Toll-like receptors and complement. IMMUNOLOGY LETTERS, 178. pp. 37-44. ISSN 0165-2478

[img] Text
pagination_IMLET_5903.pdf
Restricted to Registered users only

Download (567kB)

Abstract

Abstract B cell functions triggered by the clonally-rearranged antigen-specific B cell receptor (BCR) are regulated by several germ-line encoded receptors – including Toll-like receptors (TLRs) and complement receptors (CRs). Simultaneous or sequential engagement of these structures expressed either on the cell membrane or intracellularly, may fundamentally alter and fine tune activation, antibody and cytokine production of B cells. Here we review the expression and function of TLRs and various C3 fragment binding CRs on B cells, emphasizing their role in different human B cell subsets under physiological and pathological conditions. Studies underlining the importance of the crosstalk between TLRs and CRs in regulating B cell functions are also highlighted.

Item Type: Article
Uncontrolled Keywords: Crosstalk; TLR; Complement system; B cells
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia > QR180 Immunology / immunológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 02 Feb 2017 15:08
Last Modified: 02 Feb 2017 15:08
URI: http://real.mtak.hu/id/eprint/47320

Actions (login required)

Edit Item Edit Item