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Pharmacological Targeting of the Inflamed Intestinal Barrier

Farkas, Elek Attila and Nusrat, Asma (2016) Pharmacological Targeting of the Inflamed Intestinal Barrier. CURRENT PHARMACEUTICAL DESIGN, 22 (35). pp. 5400-5414. ISSN 1381-6128

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Abstract

The intestinal epithelium serves as an important barrier between luminal contents and underlying tissue compartments. Barrier properties are established and maintained by the multiprotein complexes in the tight junction (TJ), adherens junction (AJ) and desmosomes (DM). Compromised intestinal epithelial barrier function resulting from changes in junctional protein expression and organization is associated with exposure to luminal antigens that result in mucosal inflammation, which in turn further exacerbates the epithelial barrier compromise. In this review we discuss regulatory mechanisms by which intercellular junction proteins are influenced by inflammatory mediators to influence intestinal epithelial barrier function and address potential therapeutic strategies to strengthen the barrier and restore mucosal homeostasis.

Item Type: Article
Uncontrolled Keywords: NF-KAPPA-B; 2ND EXTRACELLULAR LOOP; COLONIC CROHNS-DISEASE; SULFATE-INDUCED COLITIS; INTEGRAL MEMBRANE-PROTEIN; ACTIVE ULCERATIVE-COLITIS; TUMOR-NECROSIS-FACTOR; TIGHT JUNCTION PERMEABILITY; CLOSTRIDIUM-PERFRINGENS ENTEROTOXIN; INFLAMMATORY-BOWEL-DISEASE; desmosome; adherens junction; tight junction; Mucosal inflammation; intestinal epithelial barrier function; Intercellular Junctions; epithelium
Subjects: R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 03 Feb 2017 10:27
Last Modified: 03 Feb 2017 10:27
URI: http://real.mtak.hu/id/eprint/47332

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