Effect of a plant-originated natural compound, CoD™ extract, on c-myc, Ha-ras and p53 gene expression in short-term animal experiments

Nádasi, E. and Prantner, I. and Dávid, T. and Ember, I. (2008) Effect of a plant-originated natural compound, CoD™ extract, on c-myc, Ha-ras and p53 gene expression in short-term animal experiments. Acta Alimentaria, 37 (1). pp. 87-92. ISSN 0139-3006

Text aalim.37.2008.1.8.pdf Restricted to Repository staff only until 31 March 2028. Download (208kB)

Abstract

Several plant-originated natural compounds were shown to exhibit chemopreventive effect in carcinogenesis. In our studies, we have investigated CoD™ extract, a complex plant extract made from several tropical plants with possible cancer preventive effect in animal experiments. c-myc, p53 and Ha-ras gene expressions were investigated 24, 48 and 72 h after CoD™ extract and dimethylbenz(a)-anthracene (DMBA) treatment in CBA/Ca(H-2K) mice. CoD™ extract administered together with DMBA diminished c-myc, p53 and Ha-ras gene expressions both in the 24 and 48 h experiments, but not in the 72 h experiments. Further in vivo and human studies are needed to clarify the possible role of CoD™ extract in the prevention of tumour formation after carcinogenic exposures.

Actions (login required)

Edit Item