Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo.

Vujošević, M. and Blagojević, Jelena (2004) Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo. Acta Veterinaria Hungarica, 52 (4). pp. 439-443. ISSN 0236-6290

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Abstract

Naturally occurring antimutagenic factors, especially those of plant origin, have recently become a subject of intensive research. Antimutagenic properties of terpenoid fractions of sage (Salvia officinalis) were tested in mammalian system in vivo through examining the ability of sage to decrease the frequency of aberrant cells induced by a potent mutagen. First, groups of mice were treated with three concentrations of sage alone and it was established that the frequency of aberrant cells after treatment with a concentration of 25 µL/kg was not significantly different from the negative control (olive oil), while that found after treatment with the 50 µL/kg concentration differed significantly (X2(1)= 4.05, p < 0.05). Sage used at a concentration of 100 µL/kg was cytotoxic. Mitomycin C (MMC), known as a potent mutagen, was used for induction of chromosome aberrations. Post-treatment with sage suppressed the effects of MMC significantly. Both concentrations (25 µL/kg and 50 µL/kg) produced a significant decrease in the frequency of aberrations relative to MMC (X2(1) = 5.42, p < 0.02, X2(1) = 14.93, p < 0.001, respectively). The percent of aberrations decreased with increasing concentrations of sage. Only nontoxic concentrations of sage without mutagenic effects can be recommended for use as inhibitors of mutagenesis or carcinogenesis.

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