Experimental autologous substitute vascular graft for transplantation surgery

Kóbori, L. and Dallos, G. and Gouw, Anette S. H. and Németh, Tamás and Nemes, B. and Fehérvári, I. and Tegzess, A. M. and Slooff, M. J. H. and De Jong, K. P. and Perner, F. (2000) Experimental autologous substitute vascular graft for transplantation surgery. Acta Veterinaria Hungarica, 48 (3). pp. 355-360. ISSN 0236-6290

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Vascular complications in liver transplantation are a major cause of graft failure and mortality. The aim of the study was to create autologous vascular graft without risk of rejection. Posterior rectus fascia sheath lined with peritoneum was used for iliac artery replacement in seven mongrel dogs. The patency was followed by palpation and Doppler ultrasound. The grafts were removed after one month. Five grafts remained patent. The Doppler showed good, relatively increased flow (median flow rate: 383 cm/sec) after one month in all of the cases. Slight increase in diameter was present in all cases. By microscopy the five patent grafts showed viable morphology, fibroblasts, smooth muscle cells and thin fibrin layer in the wall. The grafts were lined partially with a neoendothelial monolayer and a thin fibrin layer. In conclusion, this graft presents an acceptable patency rate and low thrombogenicity, and could be useful in transplantation. Further investigations are needed to study the effect of immunosuppression and rejection on long-term morphology and patency of the grafts.

Item Type: Article
Subjects: S Agriculture / mezőgazdaság > SV Veterinary science / állatorvostudomány
Depositing User: xKatalin xBarta
Date Deposited: 20 Feb 2017 12:00
Last Modified: 20 Feb 2017 12:00

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