Lipid intake and serum cholesterol level in cystic fibrosis patients

Greiner, E. and Újhelyi, R. and Sólyom, E. and Bíró, L. and Mozsáry, E. and Regölyi-Mérei, A. and Antal, M. and Madarasi, A. (1999) Lipid intake and serum cholesterol level in cystic fibrosis patients. Acta Alimentaria, 28 (4). pp. 371-378. ISSN 0139-3006

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Abstract

The authors evaluated the data of 30 patients with cystic fibrosis (18 male, 12 female), between ages 2–18 (average age: 9.57 years). In 60% of the patients serum cholesterol was below the 5th percentile value according to the data of theNational Cholesterol Education Program(1991). They examined the connection between the serum cholesterol levels and the total fat, fatty acids and cholesterol intake. No significant differences were found between total fat, fatty acids and cholesterol intake of patients with serum cholesterol levels below the 5th percentile value and patients with levels above the 5th percentile value. The analysis of the nutritional data showed that lipid intake was in accordance with the proportion prescribed for patients with CF (35.56% of energy). The intakes of saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) were 11%, 11% and 8,3% of total energy, respectively, the PUFA/SFA ratio was 0.78. The ratio of linoleic to alfa-linolenic acid was especially high: 29. The clinical condition of the patients in the low cholesterol level group, as shown by the Shwachman-Kulczycki score was significantly lower (P<0.05) than that of the group with serum cholesterol levels above the 5th percentile value. The authors therefore suggest the importance of the regular monitoring of serum cholesterol levels in patients with cystic fibrosis. Observing the changes in serum cholesterol levels is a fast, informative and inexpensive method of evaluating the clinical course of the disease.

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