REAL

Which way does the citric acid cycle turn during hypoxia? The critical role of alpha-ketoglutarate dehydrogenase complex

Chinopoulos, Christos (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of alpha-ketoglutarate dehydrogenase complex. JOURNAL OF NEUROSCIENCE RESEARCH, 91 (8). pp. 1030-1043. ISSN 0360-4012

[img]
Preview
Text
Which_way_does_the_citric_acid_cycle_turn_during_hypoxia_u.pdf

Download (1MB) | Preview

Abstract

The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the alpha-ketoglutarate dehydrogenase complex dictating their directionalities. (c) 2013 Wiley Periodicals, Inc.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 17 Jul 2017 16:28
Last Modified: 17 Jul 2017 16:28
URI: http://real.mtak.hu/id/eprint/56447

Actions (login required)

View Item View Item