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Kinetics of fumonisin B <sub>1</sub> in pigs and persistence in tissues after ingestion of a diet containing a high fumonisin concentration

Szabó-Fodor, Judit and Kametler, László and Pósa, Roland and Mamet, Rene and Rajli, Veronika and Bauer, Johann and Horn, Péter and Kovács, Ferenc and Kovács, Melinda (2008) Kinetics of fumonisin B <sub>1</sub> in pigs and persistence in tissues after ingestion of a diet containing a high fumonisin concentration. Cereal Research Communications, 36 (Supple). pp. 331-336. ISSN 0133-3720

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Abstract

The absorption, distribution and elimination of fumonisin B <sub>1</sub> (FB <sub>1</sub> ) and its metabolites was investigated in pigs. For the determination of the absorption and biotransformation of FB <sub>1</sub> , T-cannula were implanted into the distal part of experimental pigs’ ileum and the total urine and faeces moiety was collected during the toxin feeding (45 mg FB <sub>1</sub> /kg diet, duration: 10 days) and in the subsequent elimination period (10 days). At the end of trial several organs, muscle and fat samples were also collected. The accumulative absorption of fumonisin B <sub>1</sub> was 4%. In the chymus, the FB <sub>1</sub> conversion to aminopentol (totally hydrolysed FB <sub>1</sub> ; AP <sub>1</sub> ) and partially hydrolysed FB <sub>1</sub> (PHFB <sub>1</sub> ) was 1% and 3.9%, respectively. Derivatives of FB <sub>1</sub> were mostly accumulated in the liver and kidney, while in negligible concentration could be detected in the muscle and fat samples. In the organs the efficacy of the FB <sub>1</sub> to AP <sub>1</sub> and PHFB <sub>1</sub> conversion was 30% and 20%, respectively. In the faecal content the main hydrolised product was PHFB <sub>1</sub> (47%), with 12% of AP <sub>1</sub> . 1.5% of the FB <sub>1</sub> quantity taken up was excreted with the urine, about 35% in hydrolyzed form. Detectable amounts of FB <sub>1</sub> and its metabolites were measured in most of the organs, in faeces and urine even 10 days after the feeding of the noncontaminated diet. As a general conclusion, the intestinal microbiota of pigs is able to transform the intact FB <sub>1</sub> to a similarly toxic substance (partially hydrolyzed FB <sub>1</sub> ) or to a more toxic metabolite (aminopentol).

Item Type: Article
Subjects: S Agriculture / mezőgazdaság > S1 Agriculture (General) / mezőgazdaság általában
Depositing User: Barbara Payer
Date Deposited: 16 Nov 2017 19:18
Last Modified: 16 Nov 2017 19:18
URI: http://real.mtak.hu/id/eprint/59702

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