Co-infections with Hepatitis G and TT Virus in Patients with Chronic Hepatitis C in Hungary

Pár, A. and Takács, Mária and Brojnás, Judit and Berencsi, Gy. and Paál, Mária and Horányi, Margit and Miseta, A. and Hegedűs, G. and Mózsik, Gy. and Hunyady, B. (2004) Co-infections with Hepatitis G and TT Virus in Patients with Chronic Hepatitis C in Hungary. Acta Microbiologica et Immunologica Hungarica, 51 (4). pp. 437-447. ISSN 1217-8950

[img] Text
Restricted to Repository staff only until 31 December 2024.

Download (451kB)


The significance of co-infections with novel hepatitis viruses Hepatitis G (GBV-C, HGV) and TT virus (TTV) in chronic hepatitis C is not clear. We determined the prevalence of HGV RNA and TTV DNA in chronic hepatitis C patients and in asymptomatic hepatitis C virus (HCV) carriers, and assessed the influence of these agents on the course of HCV infection.  Seventy-seven patients with chronic hepatitis C - 50 of them treated with interferon (IFN) - and 33 HCV carriers with normal alanine aminotransferase have been investigated. Previous HBV infection was detected by testing serum HBsAg and aHBc. HGV RNA and TTV DNA were detected by PCR. In the healthy population, the prevalence of anti-HCV was 0.3%, HGV RNA 8.0% and TTV DNA 18.5%. In chronic hepatitis C HGV RNA occurred in 9.09% and TTV DNA in 40.25% of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20% vs. 45.7% found in non-responders. Among asymptomatic HCV-carriers, the prevalence of HGV RNA was 9.09% and TTV DNA 75.7%. Neither HGV RNA nor TTV DNA had apparent effect on the HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
Depositing User: xFruzsina xPataki
Date Deposited: 12 Sep 2017 05:19
Last Modified: 12 Sep 2017 05:19

Actions (login required)

Edit Item Edit Item