Immunohistochemical analysis of granzyme B in non-perforated appendicitis

Suyarsono, and Budyani, Dyah R. and Sosroseno, Wihaskoro (2009) Immunohistochemical analysis of granzyme B in non-perforated appendicitis. Acta Microbiologica et Immunologica Hungarica, 56 (2). pp. 191-195. ISSN 1217-8950

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Abstract

The aim of the present study was to determine the expression of granzyme B in non-perforated appendicitis. Appendix biopsies were obtained from the patients with clinically diagnosed as acute appendicitis and subjects admitted for elective abdominal surgery. All biopsies from the patients were non-perforated and histologically divided into acute and non-acute appendicitis. Granzyme B expression was assessed immunohistochemically. The results showed that granzyme B expression in both acute and non-acute appendicitis was significantly lower than that in the control appendix tissues ( P <0.05). The expression of this cytotoxic protein in acute and non-acute appendicitis was comparable ( P >0.05). Therefore, the results of the present study suggest that reduced expression of granzyme B in non-perforated appendicitis may reflect low cytotoxic activities which may prevent tissue damage.

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