REAL

The N-terminal 303 amino acids of the human cytomegalovirus envelope glycoprotein B (UL55) and the exon 4 region of the major immediate early protein 1 (UL123) induce a cytotoxic T-cell response

Berencsi, K. and Gönczöl, Éva and Endrész, Valéria and Gyulai, Zsófia (1996) The N-terminal 303 amino acids of the human cytomegalovirus envelope glycoprotein B (UL55) and the exon 4 region of the major immediate early protein 1 (UL123) induce a cytotoxic T-cell response. VACCINE, 14 (5). pp. 369-374. ISSN 0264-410X

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Abstract

We reported earlier that an adenovirus (Ad) recombinant expressing the full-length human cytomegalovirus (HCMV) glycoprotein B (gB) gene induces gB-specific cytotoxic T lymphocyte (CTL) responses in CBA (H-2(k)) mice (Berencsi et al., J. Gen. Virol. 74, 257-2512, 1993). Here we show that mice immunized with Ad recombinant viruses expressing truncated forms of the gB gene containing the first 700 (Ad-700), 465 (Ad-465) or 303 (Ad-303) amino acids of gB or an Ad construct containing exon 4 (E4) of the HCMV immediate early 1 (IE1) gene (Ad-IE1 (E4)) demonstrate HCMV-specific CTL responses, These data suggest the importance of the first 303 amino acids of the gB polypeptide and the IE1 E4 product in designing a vaccine to induce anti-HCMV CTL responses.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia > QR180 Immunology / immunológia
R Medicine / orvostudomány > RZ Other systems of medicine / orvostudomány egyéb területei
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 30 Aug 2013 11:25
Last Modified: 30 Aug 2013 11:25
URI: http://real.mtak.hu/id/eprint/6361

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