The effect of adrenomedullin, amylin fragment8-37 and calcitonin gene-related peptide on contractile force, heart rate and coronary perfusion pressure in isolated rat hearts

Kaygısız, Z. and Erkasap, N. and Uyar, R. and Kabadere, S. and Kabadere, T.E. and Dernek, S. (2003) The effect of adrenomedullin, amylin fragment8-37 and calcitonin gene-related peptide on contractile force, heart rate and coronary perfusion pressure in isolated rat hearts. Acta Physiologica Hungarica, 90 (2). pp. 133-146. ISSN 0231-424X

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Abstract

The effect of human adrenomedullin, human amylin fragment8-37 and rat calcitonin gene-related pepted (CGRP)on contractile force, heart rate and coronary perfusion pressure has been investigated in the isolated perfused rat hearts. Adrenomedulllin (2x10-10, 2x10-9 and 2-10-8 M) produced a significant decrease in contractile force and perfusion pressure, but only the peptide caused a decline in heart rate at the highest dose. Amylin (10-9, 10-8 and 10-7 M) significantly increased and then decreased contractile force. Two doses of amylin (10-8 and 10-7 M) induced a significant increase in heart rate, however amylin did not change perfusion pressure in all the doses used. Rat aplha CGRP (10-8, 10-7 and 10-6 M) evoked a slight decline in contractile force following a significant increasing in contractile force induced by the peptide. CGRP in all the doses raised heart rate and lowered perfusion pressure. Our results suggest that adrenomedullin has negative inotropic, negative chronotropic and coronary vasodilator actions. Amylin prduces a biphasic intropic effect and evokes a positive chronotropy. CGRP causes positive inotropic, positive chronotropic and vasodilatory effects in isolated rat hearts.

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