Nervous system effects in rats on subacute exposure by lead-containing nanoparticles via the airways.

Oszlánczi, Gábor and Papp, András and Szabó, Andrea and Nagymajtényi, László and Sápi, András and Kónya, Zoltán and Paulik, Edit and Vezér, Tünde (2011) Nervous system effects in rats on subacute exposure by lead-containing nanoparticles via the airways. INHALATION TOXICOLOGY, 23 (4). pp. 173-181. ISSN 0895-8378

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Abstract

Context and objective: Lead (Pb) is a heavy metal harmful for human health and environment. From leaded gasoline (still used in certain countries), and in Pb processing and reprocessing industries, airborne particles are emitted which can be inhaled. In such exposure, the size of particles entering the airways is crucial. The nervous system is a primary target for Pb, and consequences like occupational neuropathy and delayed mental development of children are wellknown. The aim of this work was to investigate the neurotoxicity of Pb nanoparticles (NPs) applied into the airways of rats.

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