CASTRATION-INDUCED HYPERACTIVITY OF SEMINAL VESICLE IN THE CATFISH CLARIAS BATRACHUS: A CASE OF PARADOX AND BLOCKADE BY ANTIANDROGEN (CYPROTERONE ACETATE) TREATMENT

Singh, M. S. and Joy, K. P. (2001) CASTRATION-INDUCED HYPERACTIVITY OF SEMINAL VESICLE IN THE CATFISH CLARIAS BATRACHUS: A CASE OF PARADOX AND BLOCKADE BY ANTIANDROGEN (CYPROTERONE ACETATE) TREATMENT. Acta Biologica Hungarica, 52 (1). pp. 91-103. ISSN 0236-5383

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Abstract

Castration of the catfish Clarias batrachus in late preparatory-early prespawning phase (AprilŚMay) caused time-dependent stimulatory effect on morphology, weight, and in the concentrations of biochem- ical correlates, such as total proteins, fructose, hexosamines and sialic acid in the seminal vesicle (SV). The peak changes were noticed on week 4 of castration. The hyperactivity was related to augmented pro- duction of testosterone by the SV of castrates with the levels significantly high from week 3 onwards. As a result, serum testosterone level fluctuated with a significant decrease in the first and fifth weeks, a sig- nificant increase in the third week, and no significant difference in the second and fourth weeks. Serum E2 level decreased significantly throughout. Cyproterone acetate treatment (CA; 1 mg/fish daily for 21 days) from the second day of castration decreased the size and weight of the SV and the concentrations of total proteins, hexosamines, fructose and sialic acid. The antiandrogen treatment did not alter serum testosterone level but the E2 level was significantly decreased. It is concluded that the hypersecretory activity of the SV in castrates is a sequel to local synthesis and action of testosterone and the effect could be prevented by CA by blocking androgen actions.

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