Recent findings on the pathogenesis of bronchial asthma

Székely, J.I. and Pataki, Á. (2009) Recent findings on the pathogenesis of bronchial asthma. Acta Physiologica Hungarica, 96 (4). pp. 385-405. ISSN 0231-424X

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Abstract

In the first part of this series of papers (Székely and Pataki, 102) the pathogenesis of asthma was approached as a pathological antigen-antibody complex induced vago-vagal axon reflex. In the next part (103) the contribution of individual hormonal predisposition, the environmental and the most frequent allergizing factors have been reviewed. In the first section of this last (third) part of the review the genetic factors contributing to the asthma are surveyed. In this field a great progress has been made during the last decade, a lot of genes have been pinpointed which contribute to the heredity of the disease. In the second section of this last paper on the etiology of asthma an attempt is made to summarize the previously reviewed data and some new ones. Actually a new hypothesis is proposed that beyond the multitude of genetic, environmental and hormonal factors the underlying biochemical mechanism is simple: the disequilibrium of two functionally opposing second messenger systems in the airways: the Cai++ liberating PLC-PKC cascade and the Cai++ level reducing cAMP mediated one with preponderance of the former.

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