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Numerical alterations of ageing B lymphocyte subsets (Review)

Ongrádi, Joseph and Kövesdi, V. (2011) Numerical alterations of ageing B lymphocyte subsets (Review). Acta Physiologica Hungarica, 98 (2). pp. 99-104. ISSN 0231-424X

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Abstract

The global population is ageing. Elderly people suffer from more severe infections than younger persons. The major reason for the increased susceptibility to infections in the elderly is the deregulated functions of the immune system. Immunosenescence affects both innate and adaptive immune reactions. Among these, quantitative alterations of B lymphocyte subsets determine outcome of infections and vaccination. The overall number of B cells seems to be stable or the decrease is moderate. Reduced input of naive B lymphocytes is compensated by anergic, exhausted memory cells. Concerning B lymphocyte subsets, experimental data obtained in the mouse model and in vivo studies conducted in old-age humans are frequently controversial. Further analysis of human B lymphocyte subpopulations is required that could be regarded as an important biomarker of human life span.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: xFruzsina xPataki
Date Deposited: 22 Nov 2017 08:25
Last Modified: 22 Nov 2017 08:25
URI: http://real.mtak.hu/id/eprint/67590

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