Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis

Simons, Sami O. and Kristiansen, Jette E. and Hajós, György and Laan, Tridia van der and Molnár, József and Boeree, Martin J. and Ingen, Jakko van and Christensen, Jørn B. and Viveiros, Miguel and Riedl, Zsuzsanna and Amaral, Leonard and Soolingen, Dick van (2013) Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis. International Journal of Antimicrobial Agents, 41 (5). pp. 488-489. ISSN 0924-8579

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Organosilicon compounds are efflux pump inhibitors with potency as an antituberculosis drug. Of the organisilicon compounds tested, SILA 421 has been shown to have a highest potency as an antituberculosis drug (1). It shares the common pathways for antimycobacterial killing with other efflux pump inhibitors: it revealed direct in vitro activity against M. tuberculosis (1), it has been shown to modify resistance by inhibiting mdr-1 efflux pumps and has shown to enhance killing of M. tuberculosis by macrophages (1).

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia
Depositing User: Dr. xAranka xPilbáth
Date Deposited: 07 Oct 2013 06:23
Last Modified: 07 Oct 2013 06:57

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