N-acetil-L-cysteine and 2-amino-2-thiazoline N-acetyl-L-cysteinate as a possible cancer chemopreventive agents in murine models

Šimkevičiené, Vitalija and Straukas, J. and Uleckiené, Saulé (2002) N-acetil-L-cysteine and 2-amino-2-thiazoline N-acetyl-L-cysteinate as a possible cancer chemopreventive agents in murine models. Acta Biologica Hungarica, 53 (3). pp. 293-298. ISSN 0236-5383

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Abstract

The aim of this study was to investigate N-acetyl-cysteine (NAC) and its 2-amino-2-thiazoline salt (NACAT) as potential chemopreventive agents on experimentally induced lung tumours by urethane (U) in mice. Female BALB/c mice were used. U was given by intraperitoneal injections during 2 weeks (single dose – 10 mg/mouse, total – 50 mg/mouse). Mice were treated daily per os with NAC 1/10 LD50, NACAT 1/10 or 1/100 LD50 starting 2 weeks prior U administration, then during U treatment and thereafter for 2 months. The duration of experiment was 4 months. The results showed that NAC (1000 mg/kg) reduced the lung tumour incidence to 30% that of controls, P ˛ 0.05. Most effective of NACAT was 100 mg/kg dose; it reduced an average of lung adenomas per mouse by 26%, P ˛ 0.05, but lower dose (10 mg/kg) was less effective. In order to achieve similar chemopreventive effect (~30%) on mice, it is necessary to use 0.38 mM/kg of NACAT or 6.13 mM/kg of NAC. It means that 16 times less of NACAT is required, if calculated by molar concentration. In general, NAC and NACAT have a moderate chemopreventive effect on lung tumorigenesis induced by urethane in mice.

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