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Pacemaker potentials are the physiologic basis of epileptiform activity in the buccal ganglia of Helix pomatia

Altrup, U. (2004) Pacemaker potentials are the physiologic basis of epileptiform activity in the buccal ganglia of Helix pomatia. Acta Biologica Hungarica, 55 (1-4). pp. 261-268. ISSN 0236-5383

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Abstract

Epileptic activity of neurons consists of paroxysmal depolarization shifts (PDS) which can be induced presumably in any nervous system by application of an epileptogenic drug. The spontaneous appearance of epileptic activity, however, is based on a largely unknown process which increases susceptibility to epileptic activity (seizure susceptibility in man). It is presently shown that the treatment of ganglia with proteolytic enzymes (Pronase) decreases the effective concentration of epileptogenic drugs, i.e. increases seizure susceptibility. Since proteolytic enzymes are known to primarily affect glial cells a contribution of glia to seizure susceptibility is discussed.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz
Depositing User: Endre Sarvay
Date Deposited: 13 Nov 2017 16:29
Last Modified: 13 Nov 2017 16:29
URI: http://real.mtak.hu/id/eprint/69910

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