REAL

The effect of pinealectomy on plasma vasopressin response to isotonic, hypertonic and hypovolemic treatments in rats supplemented with L-thyroxine

Mogulkoc, R. and Baltaci, A. (2008) The effect of pinealectomy on plasma vasopressin response to isotonic, hypertonic and hypovolemic treatments in rats supplemented with L-thyroxine. Acta Biologica Hungarica, 59 (2). pp. 163-172. ISSN 0236-5383

[img] Text
abiol.59.2008.2.3.pdf
Restricted to Repository staff only until 30 June 2028.

Download (421kB)

Abstract

The present study was conducted to determine the effects of basal, isotonic as well as hypertonic and hypovolemic treatments on fluid-electrolyte balance and plasma AVP levels in rats supplemented with L-thyroxine and pinealectomized L-thyroxine. The animals were initially separated into 4 groups: control (n = 24), L-thyroxine treated (n = 24); L-thyroxine + sham-pinealectomy (n = 24) treated and 4-Lthyroxine + pinealectomy (n = 24) treated. L-thyroxine was given for 4 weeks. At the end of the 4-week experimental period, the sub-groups were formed before decapitation, which were classified as unstimulated (n = 6), isotonic (n = 6), hypertonic (n = 6) and hypovolemic (n = 6) stimulation. Plasma AVP, total triiodothyronine (TT <sub>3</sub> ) and total thyroxine (TT <sub>4</sub> ) levels were examined in plasma by RIA. Hematocrit and osmolality levels were also determined. It was found that the TT <sub>3</sub> and TT <sub>4</sub> levels showed significant increases in L-thyroxine treated groups (P < 0.001). Also, plasma AVP levels increased in the group subjected to L-thyroxine treatment. However, this increase was depicted to be significantly more prominent in L-thyroxine + pinealectomy treated group (P < 0.001). The results of the present study indicate that Lthyroxine treatment increases the basal and stimulated AVP release, which became more significant in the pinealectomy plus L-thyroxine treatment group. Moreover, the results indicate that AVP response to hypertonic and hypovolemic stimulations does not undergo any change due to supplementation by L-thyroxine treatment and/or pinealectomy plus L-thyroxine.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz
Depositing User: Endre Sarvay
Date Deposited: 20 Nov 2017 15:46
Last Modified: 20 Nov 2017 15:46
URI: http://real.mtak.hu/id/eprint/70173

Actions (login required)

Edit Item Edit Item