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Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice

Vereczki, Viktória and Mansour, Josef and Pour-Ghaz, Issa and Bodnár, Ibolya and Pintér, Ottó and Oszwald, Erzsébet and Ádám, Veronika and Chinopoulos, Christos (2017) Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice. Mitochondrion, 34. pp. 115-126. ISSN 1567-7249, ESSN: 1872-8278

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Abstract

Abstract Cyclophilin D (cypD) modulates the properties of the permeability transition pore, a phenomenon implicated in the manifestation of many diseases including aging. Here, we examined the effects of partial or complete deletion of cypD on i) lifespan, ii) forebrain protein expression of 18 aging markers as well as regional expression of GFAP, mGluR1, and alpha-synuclein, and iii) behaviour of aged (> 24 month) male and female mice. Both male and female cypD heterozygous but not KO mice exhibited increased lifespans compared to WT littermates, associated with alterations in the protein expression of some markers, albeit without exhibiting changes in behaviour.

Item Type: Article
Uncontrolled Keywords: Mitochondria; heterozygote; PERMEABILITY TRANSITION; ALPHA-SYNUCLEIN; mGluR1; GFAP
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 12 Mar 2018 12:30
Last Modified: 12 Mar 2018 12:31
URI: http://real.mtak.hu/id/eprint/78015

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