Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates

Bacsa, Ildikó and Konc, Csilla and Orosz, Anna Boglárka and Kecskeméti, Gábor and Rigó, Réka and Laczka, Csilla and Mernyák, Erzsébet (2018) Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates. MOLECULES, 23 (4). p. 821. ISSN 1420-3049

Preview

Text molecules_23_00821_u.pdf Download (1MB) | Preview

Abstract

Novel BODIPY–estrone conjugates were synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). Estrone-alkynes or an estrone-azide as starting compounds were synthesized via Michael addition or Sonogashira reaction as key steps. Fluorescent dyes based on BODIPY-core were provided by azide or alkyne functional groups. Fluorescent labeling of estrone was efficiently achieved at the C-2 or C-15 position. The newly-elaborated coupling procedures might have a broad applicability in the synthesis of fluorescent-labeled estrone conjugates suitable for biological assays. © 2018 by the authors.

Actions (login required)

Edit Item