Dose dependent hepatotoxic effects of dry seed phaseolus vulgaris linn. (red kidney beans) on rabbits

Siddiq, A. and Hasan, A.M. and Alam, S. (2018) Dose dependent hepatotoxic effects of dry seed phaseolus vulgaris linn. (red kidney beans) on rabbits. Acta Alimentaria, 47 (3). pp. 291-297. ISSN 0139-3006

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Abstract

Growing research on beans suggest that they are good for health, as they reduce the risk and/or help in the management of chronic diseases. Beans are valuable parts of several dietary recommendations. Saponins, α-galactosides, phytates, and lectins are currently drawing attention because of their diverse properties, both adverse and beneficial. The aim was to determine the hepatotoxic effect of dry red kidney beans, i.e. Phaseolus vulgaris, on rabbits at 4 g kg^–1, 6 g kg^–1, and 8 g kg^–1 dosing for the period of 30 days. The histopathological examination revealed inflammation of hepatocyte at all three doses along with congestion. The biochemical testing of liver enzymes revealed elevated alanine transaminase (ALT), aspartate transaminase (AST) and gamma-glutamyl transferase (γ-GT). The dose-dependent increase in liver enzymes indicates the hepatotoxic effect of dry red kidney beans, and various studies have demonstrated that lectins are the toxic components responsible for inflammation of body organs.

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