REAL

Antibacterial effect of microvesicles released from human neutrophilic granulocytes

Tímár, Csaba and Lőrincz, Márton Ákos and Csépányi-Kömi, Roland and Vályi-Nagy, Anna and Nagy, György and Buzás, Edit Irén and Iványi, Zsolt and Kittel, Ágnes and Ligeti, Erzsébet (2013) Antibacterial effect of microvesicles released from human neutrophilic granulocytes. BLOOD, 121 (3). pp. 510-518. ISSN 0006-4971

[img] Text
kittel2.pdf
Restricted to Repository staff only

Download (532kB) | Request a copy

Abstract

Cell-derived vesicles represent a recently discovered mechanism for intercellular communication. In the present study we investigated their potential role in interaction of microbes with host organisms. We provide evidence that different stimuli induced isolated neutrophilic granulocytes to release microvesicles with different biological properties. Only opsonized particles initiated the formation of microvesicles that were able to impair bacterial growth. The antibacterial effect of neutrophil-derived microvesicles was independent of production of toxic oxygen metabolites and opsonization or engulfment of the microbes, but depended on β2 integrin function, continuous actin remodeling and on the glucose supply. Neutrophil-derived microvesicles were detected in the serum of healthy donors, and their number was significantly increased in the serum of bacteremic patients. We propose a new extracellular mechanism to restrict bacterial growth and dissemination.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 09 Jan 2014 11:44
Last Modified: 15 Jan 2014 14:41
URI: http://real.mtak.hu/id/eprint/8533

Actions (login required)

Edit Item Edit Item