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Gap junctions compensate for sublinear dendritic integration in an inhibitory network

Vervaeke, K. and Lőrincz, Andrea and Nusser, Zoltán and Silver, R. A. (2012) Gap junctions compensate for sublinear dendritic integration in an inhibitory network. SCIENCE, 335 (6076). pp. 1624-1628. ISSN 0036-8075

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Abstract

Electrically coupled inhibitory interneurons dynamically control network excitability, yet little is known about how chemical and electrical synapses regulate their activity. Using two-photon glutamate uncaging and dendritic patch-clamp recordings, we found that the dendrites of cerebellar Golgi interneurons acted as passive cables. They conferred distance-dependent sublinear synaptic integration and weakened distal excitatory inputs. Gap junctions were present at a higher density on distal dendrites and contributed substantially to membrane conductance. Depolarization of one Golgi cell increased firing in its neighbors, and inclusion of dendritic gap junctions in interneuron network models enabled distal excitatory synapses to drive network activity more effectively. Our results suggest that dendritic gap junctions counteract sublinear dendritic integration by enabling excitatory synaptic charge to spread into the dendrites of neighboring inhibitory interneurons.

Item Type: Article
Uncontrolled Keywords: synaptic transmission; Synapses/physiology; Patch-Clamp Techniques; *Neural Inhibition; Nerve Net/*physiology/ultrastructure; Models, Neurological; Mice, Knockout; Mice, Inbred C57BL; MICE; Ion Channels/physiology; Interneurons/*physiology; Excitatory Postsynaptic Potentials; Electrical Synapses/*physiology/ultrastructure; Dendrites/*physiology/*ultrastructure; Computer simulation; Cerebellar Cortex/cytology; Axons/physiology; Animals; Action Potentials
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 01 Oct 2018 08:07
Last Modified: 01 Oct 2018 08:07
URI: http://real.mtak.hu/id/eprint/86119

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