Matrix systems for oral drug delivery: Formulations and drug release

Vasvári, Gábor and Kalmár, József and Veres, Péter and Vecsernyés, Miklós and Bácskay, Ildikó and Siposné Fehér, Pálma and Ujhelyi, Zoltán and Haimhoffer, Ádám and Rusznyák, Ágnes and Fenyvesi, Ferenc and Váradi, Judit (2018) Matrix systems for oral drug delivery: Formulations and drug release. DRUG DISCOVERY TODAY: TECHNOLOGIES, 27. pp. 71-80. ISSN 1740-6749

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Abstract

In this current article matrix formulations for oral drug delivery are reviewed. Conventional dosage forms and novel applications such as 3D printed matrices and aerogel matrices are discussed. Beside characterization, excipients and matrix forming agents are also enlisted and classified. The incorporated drug could exist in crystalline or in amorphous forms, which makes drug dissolution easily tunable. Main drug release mechanisms are detailed and reviewed to support rational design in pharmaceutical technology and manufacturing considering the fact that R&D members of the industry are forced to obtain knowledge about excipients and methods pros and cons. As innovative and promising research fields of drug delivery, 3D printed products and highly porous, low density aerogels with high specific surface area are spreading, currently limitlessly. These compositions can also be considered as matrix formulations.

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