Prevalence of HPV infection in racial–ethnic subgroups of head and neck cancer patients

Ragin, Camille and Liu, Jeffrey C. and Jones, Gieira and Shoyele, Olubunmi and Sowunmi, Bukola and Kennett, Rachel and Gibbs, Denise and Blackman, Elizabeth and Esan, Michael and Brandwein, Margaret S. and Devarajan, Karthik and Bussu, Francesco and Chernock, Rebecca and Chien, Chih-Yen and Cohen, Marc A. and El-Mofty, Samir and Suzuki, Mikio and D’Souza, Gypsyamber and Funchain, Pauline and Eng, Charis and Gollin, Susanne M. and Hong, Angela and Jung, Yuh-S and Krüger, Maximilian and Lewis, James and Morbini, Patrizia and Landolfo, Santo and Rittà, Massimo and Straetmans, Jos and Szarka, Krisztina and Tachezy, Ruth and Worden, Francis P. and Nelson, Deborah and Gathere, Samuel and Taioli, Emanuela (2017) Prevalence of HPV infection in racial–ethnic subgroups of head and neck cancer patients. CARCINOGENESIS, 38 (2). pp. 218-229. ISSN 0143-3334

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Abstract

The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N=798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16,18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P<0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.

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