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A new division of schizophrenia revealed expanded bilateral brain structural abnormalities of the association cortices

Szendi, István and Szabó, Nikoletta and Domján, Nóra and Kincses, Zsigmond Tamás and Palkó, András and Vécsei, László and Racsmány, Mihály (2017) A new division of schizophrenia revealed expanded bilateral brain structural abnormalities of the association cortices. FRONTIERS IN PSYCHIATRY, 8 (7). ISSN 1664-0640

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Abstract

The phenomenological and, consequently, pathophysiological heterogeneity of schizophrenia may be substantially decreased by determining etiologically valid subgroups. In a cross-sectional study, we analyzed the brain structural impairments of outpatients with schizophrenia using concurrent subgrouping methods, partly to enhance the extensity of exploration, and partly to estimate the validation of the divisions. High resolution T1-weighted MR images were obtained for 21 patients and 13 healthy controls. Localized gray matter volumetric deficits were defined with optimized voxel-based morphometry. Employing two concurrent methods (i.e., the widely known deficit-non-deficit division vs. the neurocognitive clusters we identified earlier) the patient group was iteratively divided into two subgroups, and their volumetric peculiarities were compared with one another and with healthy controls. Our division revealed more significant differences demonstrating bilateral brain structural deficits, which affected the association cortices, primarily the heteromodal fields and partly the unimodal fields. This is the first study that showed that abnormalities of the association cortices can be bihemispherial and expanded in schizophrenia, even in the cases of outpatients living integrated in society. Our result suggests that the extended association cortex abnormalities could constitute substantial and determining neurological substrates in the phenomenology and aetiopathogenesis of schizophrenia, at least in a subgroup of patients with more unfavorable neurocognitive characteristics. © 2017 Szendi, Szabó, Domján, Kincses, Palkó, Vécsei and Racsmány.

Item Type: Article
Uncontrolled Keywords: HETEROGENEITY; association cortex; voxel-based morphometry; SUBGROUPS; Heteromodal brain fields;
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 14 Jan 2019 14:44
Last Modified: 14 Jan 2019 14:44
URI: http://real.mtak.hu/id/eprint/89882

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