Complement factor H family proteins in their non-canonical role as modulators of cellular functions

Józsi, Mihály and Schneider, Andrea E. and Kárpáti, Éva and Sándor, Noémi (2019) Complement factor H family proteins in their non-canonical role as modulators of cellular functions. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 85. pp. 122-131. ISSN 1084-9521

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Abstract

Complement factor H is a major regulator of the alternative pathway of the complement system. The factor H-related proteins are less characterized, but recent data indicate that they rather promote complement activation. These proteins have some common ligands with factor H and have both overlapping and distinct functions depending on domain composition and the degree of conservation of amino acid sequence. Factor H and some of the factor H-related proteins also appear in a non-canonical function that is beyond their role in the modulation of complement activation. This review covers our current understanding on this emerging role of factor H family proteins in modulating the activation and function of various cells by binding to receptors or receptor ligands.

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