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Analysis of Mammalian O-Glycopeptides-We Have Made a Good Start, but There is a Long Way to Go

Darula, Zsuzsanna and Medzihradszky F., Katalin (2018) Analysis of Mammalian O-Glycopeptides-We Have Made a Good Start, but There is a Long Way to Go. MOLECULAR AND CELLULAR PROTEOMICS, 17 (1). pp. 2-17. ISSN 1535-9476

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Abstract

Glycosylation is perhaps the most common post-translational modification. Recently there has been growing interest in cataloging the glycan structures, glycoproteins, and specific sites modified and deciphering the biological functions of glycosylation. Although the results are piling up for N-glycosylation, O-glycosylation is seriously trailing behind. In our review we reiterate the difficulties researchers have to overcome in order to characterize O-glycosylation. We describe how an ingenious cell engineering method delivered exciting results, and what could we gain from "wild-type" samples. Although we refer to the biological role(s) of O-glycosylation, we do not provide a complete inventory on this topic.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 31 Jan 2019 06:56
Last Modified: 31 Jan 2019 06:56
URI: http://real.mtak.hu/id/eprint/90770

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