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Effect of chronic T-2 toxin exposure in rabbit bucks, determination of the No Observed Adverse Effect Level (NOAEL)

Kovács, Melinda and Tornyos, Gábor and Matics, Zsolt and Mézes, Miklós and Balogh, Krisztián and Rajli, Veronika and Bodnár, Zsófia and Rusvai, Miklós and Mándoki, Míra and Cseh, Sándor (2013) Effect of chronic T-2 toxin exposure in rabbit bucks, determination of the No Observed Adverse Effect Level (NOAEL). ANIMAL REPRODUCTION SCIENCE (137). pp. 245-252. ISSN 0378-4320

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Abstract

T-2 toxin (T-2) was administered to adult Pannon White (n = 10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2 mg/animal/day), and secondly mixed into the feed (0.33 and 0.66 mg/kg feed). In the first experiment 0.1 mg T-2 exposure resulted in temporary decrease in feed intake, slower increase in the gonadotropin-releasing hormone (GnRH) induced testosterone synthesis, slight centrolobular infiltration in the liver and a slight hyperplasia of the Leydig cells. In addition to the temporary feed refusal effect, 0.2 mg T-2 caused a temporary decrease in plasma albumin and urea concentrations, lesser glutathione peroxidase (GPx) activity in the seminal plasma, a greater (by 320%) ratio of spermatozoa with cytoplasmic droplets, slower increase in the GnRH-induced testosterone synthesis, centrolobular infiltration in the liver, slightly hyperaemic testes and increased proliferative activity of the Leydig cells. The two smaller doses applied in feed (0.33 and 0.66 mg/kg) did not cause any significant adverse effect, and no feed refusal was observed. According to these results the No Observed Adverse Effect Level (NOAEL) of T-2 for adult rabbit males was found to be <0.1 mg/animal/day (<0.02 mg/kg b.w./day).

Item Type: Article
Uncontrolled Keywords: T-2 toxin, Rabbit, Sperm quality, No Observed Adverse Effect Level (NOAEL)
Subjects: S Agriculture / mezőgazdaság > SV Veterinary science / állatorvostudomány
Depositing User: Diszterhöft Zoltán
Date Deposited: 30 Jan 2014 13:09
Last Modified: 05 Apr 2023 08:04
URI: http://real.mtak.hu/id/eprint/9407

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