Immunopathological findings in a cat with auricular chondritis

Wilson, Tais Meziara and Machado, Mizael and De Sousa, Davi Emanuel Ribeiro and Braúna, Tainã and Torres Neto, Rafael and Laufer-Amorim, Renée and Szabó, Matias Pablo Juan and De Castro, Marcio Botelho (2019) Immunopathological findings in a cat with auricular chondritis. Acta Veterinaria Hungarica, 67 (1). pp. 81-86. ISSN 0236-6290

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Abstract

At clinical examination, a 5-year-old male domestic short-haired cat exhibited painful swelling and erythema of the pinnae of both ears. Microscopically, the lesions on both pinnae were composed of diffuse granulomatous chondritis with degeneration and necrosis of the pinnal cartilage. Numerous mast cells were also observed within and surrounding the inflammatory lesion. Immunohistochemistry showed a mixed inflammatory infiltrate characterised by the predominance of macrophages (CD68+, MAC 387+ and Lysozyme+), T lymphocytes (CD3+), some B lymphocytes (CD79α+) and neutrophils. Immunopathological characterisation of the lesion showed a granulomatous inflammation profile and suggests that the morphological changes and immunopathogenesis of auricular chondritis in cats presents a similarity with relapsing polychondritis in humans.

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