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Antibacterial effect of orange Monascus pigment against Staphylococcus aureus

Feng, L.H. and Li, Y.Q. and Sun, G.J. and Zhao, X.Z. (2019) Antibacterial effect of orange Monascus pigment against Staphylococcus aureus. Acta Alimentaria, 48 (2). pp. 169-176. ISSN 0139-3006 (print); 1588-2535 (online)

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Abstract

The objective of this work was to research the antibacterial effects of orange pigment, which was separated from Monascus pigments, against Staphylococcus aureus. The increase of the diameter of inhibition zone treated with orange pigment indicated that orange pigment had remarkable antibacterial activities against S. aureus. Orange pigment (10 mg ml−1) had a strong destructive effect on the membrane and structure of S. aureus by the analysis of scanning electron microscopy as well as transmission electron microscopy. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) further demonstrated that the cell membrane was seriously damaged by orange pigment, which resulted in the leakage of protein from S. aureus cells. A significant decrease in the synthesis of DNA was also seen in S. aureus cells exposed to 10 mg ml−1 orange pigment. All in all, orange pigment showed excellent antibacterial effects against S. aureus.

Item Type: Article
Additional Information: MTA KFB támogatási szerződés alapján archiválva
Subjects: Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia
Depositing User: Violetta Baliga
Date Deposited: 16 Aug 2019 07:07
Last Modified: 30 Jun 2020 23:28
URI: http://real.mtak.hu/id/eprint/95733

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