Diagnosis of malaria in a traveler 9 months after returning from West Africa by illumigene® LAMP assay: A case report

Reuken, Philipp A. and Baier, Michael and Hagel, Stefan and Eisermann, Philip and Stallmach, Andreas and Rödel, Jürgen (2019) Diagnosis of malaria in a traveler 9 months after returning from West Africa by illumigene® LAMP assay: A case report. Acta Microbiologica et Immunologica Hungarica, 66 (3). pp. 301-306. ISSN 1217-8950

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Abstract

Loop-mediated isothermal amplification (LAMP) is a rapid molecular technique that has been introduced into malaria diagnosis. The test is easy to perform and offers high sensitivity. We report a 53-year-old male patient who was hospitalized with fever attacks, chills, and headache caused 9 months after returning from Africa. During his stay in Africa, he used malaria chemoprophylaxis. Microscopy of thin and thick blood films and rapid diagnostic antigen testing remained negative for three times. The EDTA blood samples were tested using the Meridian illumigene® malaria LAMP assay that gave a positive result for Plasmodium spp. Diagnosis of malaria was subsequently specified as P. ovale infection by real-time PCR. Ovale malaria often manifests with delay and low parasitemia. The patient was treated with atovaquone-proguanil, followed by primaquine for prophylaxis of relapse. This case illustrates the usefulness of the illumigene® malaria LAMP assay for initial screening of malaria parasites.

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