REAL

Nonsuppurative (Aseptic) Meningoencephalomyelitis Associated with Neurovirulent Astrovirus Infections in Humans and Animals

Reuter, Gábor and Boros, Ákos and Pankovics, Péter (2018) Nonsuppurative (Aseptic) Meningoencephalomyelitis Associated with Neurovirulent Astrovirus Infections in Humans and Animals. Clinical Microbiology Reviews, 31 (4). ISSN 1098-6618

[img]
Preview
Text
Reuter et al 2018 ASM - Astrovirus.pdf

Download (2MB) | Preview

Abstract

Astroviruses are thought to be enteric pathogens. Since 2010, a certain group of astroviruses has increasingly been recognized, using up-to-date random amplification and high-throughput next-generation sequencing (NGS) methods, as potential neurovirulent (Ni) pathogens of severe central nervous system (CNS) infections, causing encephalitis, meningoencephalitis, and meningoencephalomyelitis. To date, neurovirulent astrovirus cases or epidemics have been reported for humans and domesticated mammals, including mink, bovines, ovines, and swine. This comprehensive review summarizes the virology, epidemiology, pathology, diagnosis, therapy, and future perspective related to neurovirulent astroviruses in humans and mammals, based on a total of 30 relevant articles available in PubMed (searched by use of the terms "astrovirus/encephalitis" and "astrovirus/meningitis" on 2 March 2018). A paradigm shift should be considered based on the increasing knowledge of the causality-effect association between neurotropic as-troviruses and CNS infection, and attention should be drawn to the role of astroviruses in unknown CNS diseases.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia > QR355 Virology / víruskutatás
Depositing User: Dr. Peter Pankovics
Date Deposited: 16 Sep 2019 09:37
Last Modified: 06 Apr 2023 07:21
URI: http://real.mtak.hu/id/eprint/99462

Actions (login required)

Edit Item Edit Item