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primary topic: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities

The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities
type: AcademicArticle
type: Article
abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and chronic neuroinflammation. Mounting evidence suggests that inflammasome activation plays a pivotal role in the onset and progression of AD by promoting neuronal damage, Tau pathology, and amyloid-β (Aβ) accumulation. Among the various inflammasome types expressed in the central nervous system (CNS), NLRP3 has received particular attention due to its strong association with both AD and pain-related neuroinflammation. Chronic pain, frequently observed in older adults and individuals with dementia, shares overlapping inflammatory mechanisms with AD, including glial activation and cytokine dysregulation. The inflammasome-microRNA (miR) axis has recently emerged as a key regulatory pathway modulating these neuroinflammatory responses. Specific inflammation-associated miRs, such as miR-22, miR-34a, miR-146a, miR-155, and miR-223, influence innate immune signaling and critically affect both neuronal homeostasis and pain sensitization. Emerging evidence also implicates dysfunction of the locus coeruleus-noradrenergic (LC-NE) system—an early target of AD pathology—in amplifying neuroinflammation and pain sensitivity, partly through interactions with dysregulated miRs. While previous studies have addressed the roles of inflamma-miRs in AD or chronic pain individually, this review uniquely examines their interconnected roles—highlighting how dysregulated miR expression and inflammasome activation may converge to drive persistent neuroinflammation across both conditions. By elucidating shared molecular pathways, we propose that targeting the inflammasome-miR axis may offer dual therapeutic potential: slowing AD progression while addressing pain-related neural dysfunction. As the prevalence of AD rises, such integrated insights are essential for the development of more precise, mechanism-based interventions.
date: 2025-06-25
is part of: AGING AND DISEASE
status: peerReviewed
status: forthcoming
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Text)
has version: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Text)
has published: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Text)
has document: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Other)
subject: R850-854 Experimental medicine / kisérleti orvostudomány

The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Text)
type: Document
license: http://creativecommons.org/licenses/by/3.0/
has file: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain_ Molecular Mechanisms and Therapeutic Opportunities.pdf
has part: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain_ Molecular Mechanisms and Therapeutic Opportunities.pdf

AGING AND DISEASE
type: Collection
issn: 21525250

Matta Csaba
type: Person
given name: Matta
family name: Csaba

Fülesdi Béla
type: Person
given name: Fülesdi
family name: Béla

Benkő Szilvia
type: Person
given name: Benkő
family name: Szilvia

Takács Roland
type: Person
given name: Takács
family name: Roland

Gaál Botond
type: Person
given name: Gaál
family name: Botond

Szekanecz Zoltán
type: Person
given name: Szekanecz
family name: Zoltán

Ducza László
type: Person
given name: Ducza
family name: László

Juhász Krisztián
type: Person
given name: Juhász
family name: Krisztián

The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Other)
type: Document
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The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Other)
type: Document
is version of: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Text)
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The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Other)
type: Document
is version of: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Text)
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The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Other)
type: Document
is version of: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Text)
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The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Other)
type: Document
is version of: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities (Text)
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primary topic: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities

R850-854 Experimental medicine / kisérleti orvostudomány
type: Concept