Understanding the importance of autophagy in human diseases using Drosophila

Bhattacharjee, Arindam and Szabo, Aron and Csizmadia, Tamas and Laczko-Dobos, Hajnalka and Juhasz, Gabor (2019) Understanding the importance of autophagy in human diseases using Drosophila. Journal of Genetics and Genomics, 46. pp. 157-169. ISSN 1673-8527

Text Understanding the importance of autophagy in human diseases using Drosophila.pdf Restricted to Registered users only Download (920kB)

Abstract

Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in thepathogenesis of various human diseases, either positively or negatively impacting disease outcomesdepending on the specific context. The majority of medical conditions including cancer, neurodegener-ative diseases, infections and immune system disorders and inflammatory bowel disease could probablybenefit from therapeutic modulation of the autophagy machinery.Drosophilarepresents an excellentmodel animal to study disease mechanisms thanks to its sophisticated genetic toolkit, and the conser-vation of human disease genes and autophagic processes. Here, we provide an overview of the variousautophagy pathways observed both inflies and human cells (macroautophagy, microautophagy andchaperone-mediated autophagy), and discussDrosophilamodels of the above-mentioned diseases wherefly research has already helped to understand how defects in autophagy genes and pathways contributeto the relevant pathomechanisms.

Actions (login required)

Edit Item