Kerekes, Diána and Csorba, Attila and Gosztola, Beáta and Németh-Zámbori, Éva and Kiss, Tivadar and Csupor, Dezső (2019) Furocoumarin Content of Fennel - Below the Safety Threshold. MOLECULES, 24 (15). No.-2844. ISSN 1420-3049
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Abstract
Furocoumarins are known for their phototoxic and potential carcinogenic effects. These types of compounds have previously been reported from fennel (Foeniculum vulgare Mill.), a widely used medicinal plant and spice; however, no reliable quantitative data are available on the occurrence of these compounds in fennel fruits. For the first time, we report a comprehensive analysis of fennel fruit samples of different origins, representing a wide range of accessions for their furocoumarin content. Psoralene, 5-methoxypsoralene (bergapten), and imperatorin contents of 33 fennel samples were analyzed using a sensitive liquid chromatography-mass spectrometry (LC-MS) method. When applied at the highest therapeutic dose described in the monograph issued by the European Medicines Agency, the furocoumarin content of the fruits ranged up to 1.22 μg/d, which is below the most restrictive recommendations. Based on our findings, fennel consumption can be considered as safe, at least based on its low furocoumarin content.
| Item Type: | Article |
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| Additional Information: | Funding Agency and Grant Number: National Research, Development and Innovation Office [OTKA K115796]; Economic Development and Innovation Operative Programme [GINOP-2.3.2-15-2016-00012]; UNKP-18-4 New National Excellence Program of the Ministry of Human Capacities; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences Funding text: This work was funded by the National Research, Development and Innovation Office [OTKA K115796], the Economic Development and Innovation Operative Programme [GINOP-2.3.2-15-2016-00012], the UNKP-18-4 New National Excellence Program of the Ministry of Human Capacities, and the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. |
| Uncontrolled Keywords: | Foeniculum vulgare; fennel; psoralene; 5-methoxypsoralene; imperatorin; |
| Subjects: | R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 24 Sep 2019 06:55 |
| Last Modified: | 24 Sep 2019 06:55 |
| URI: | http://real.mtak.hu/id/eprint/100767 |
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