Kainate receptors have different modulatory effect in seizure-like events and slow rhythmic activity in entorhinal cortex ex vivo

Szádeczky-Kardoss, Katalin and Varró, Petra and Szűcs, Attila and Borbély, Sándor and Világi, Ildikó (2019) Kainate receptors have different modulatory effect in seizure-like events and slow rhythmic activity in entorhinal cortex ex vivo. BRAIN RESEARCH BULLETIN. ISSN 0361-9230 (In Press)

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Abstract

In the neocortex, neurons form functional networks, the members of which exhibit a variable degree of synchronization. Slow rhythmic activity may be regarded as a balanced interplay of excitatory and inhibitory neuronal network activity, which is essential in learning and memory consolidation. On the other hand, seizures may be considered as hypersynchronized network states occurring in epileptic diseases. The brain slice method and multi-electrode array (MEA) systems offer a good opportunity for the modelling of cortical spontaneous activities by examining their initiation and propagation. Our main goals were to characterise and compare spontaneous activities developing in different conditions and cortical network states. The role of kainate receptors in these processes was also tested. According to our results, there are demonstrable dissimilarities between slow rhythmic activities vs. seizure-like events developing in the rat entorhinal cortex ex vivo in normal vs. epileptic conditions. Propagation velocity, time scale, activity pattern and pharmacological sensitivity are all different. Kainate receptors play a role in network activity in entorhinal cortex, they are capable to prolong the duration of the events of epileptiform activity. Their regulatory effect is more prominent under epileptic than under normal conditions.

Item Type:	Article
Subjects:	Q Science / természettudomány > QP Physiology / élettan
Depositing User:	Dr Sándor Borbély
Date Deposited:	25 Sep 2019 08:04
Last Modified:	25 Sep 2019 08:04
URI:	http://real.mtak.hu/id/eprint/101167

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