Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients.

Aradi, Mihály and Schwarcz, Attila and Perlaki, Gábor and Orsi, Gergely and Kovács, Norbert and Trauninger, Anita and Kamson, David Olayinka and Erdélyi-Bótor, Szilvia and Nagy, Ferenc and Nagy, Szilvia Anett and Dóczi, Tamás and Komoly, Sámuel and Pfund, Zoltán (2013) Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients. Headache, 53 (5). pp. 752-63. ISSN 1526-4610

[img] Text
Aradi 2013 Headache.pdf - Published Version
Restricted to Repository staff only

Download (309kB) | Request a copy


OBJECTIVE The aim of this study was to examine chronic brain white matter hyperintensities in migraine and to gain data on the characteristics of the lesions. BACKGROUND Migraine associates with a higher incidence of magnetic resonance imaging (MRI)-visible white matter signal abnormalities. Several attack-related pathomechanisms have been proposed in the lesion development, including the effect of repeated intracerebral hemodynamic changes. METHODS Supratentorial white matter hyperintensities of 17 migraine patients were investigated interictally with quantitative MRI, including quantitative single voxel spectroscopy, diffusion, and perfusion MRI at 3.0-Tesla. The findings were compared with data measured in the contralateral, normal-appearing white matter of migraineurs and in the white matter of 17 healthy subjects. RESULTS Significantly higher apparent diffusion coefficient values, prolonged T2 relaxation times, and decreased N-acetyl-aspartate and creatine/phosphocreatine concentrations were found in the white matter hyperintensities. The cerebral blood flow and blood volume values were mildly decreased inside the hyperintensities. Differences were not present between the migraine patients' normal-appearing white matter and the white matter of healthy subjects. CONCLUSIONS The MRI measurements denote tissue damage with axonal loss, low glial cell density, and an enlarged extracellular space with an increased extracellular water fraction. These radiological features might be the consequences of microvascular ischemic changes during migraine attacks.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: Dr. Endre Czeiter
Date Deposited: 07 Feb 2014 06:53
Last Modified: 07 Feb 2014 06:53

Actions (login required)

Edit Item Edit Item