Bi-exponential diffusion signal decay in normal appearing white matter of multiple sclerosis.

Nagy, Szilvia A. and Aradi, Mihaly and Orsi, Gergely and Perlaki, Gabor and Kamson, David Olayinka and Mike, Andrea and Komaromy, Hedvig and Schwarcz, Attila and Kovacs, Arpad and Janszky, Jozsef and Pfund, Zoltan and Illes, Zsolt and Bogner, Peter (2013) Bi-exponential diffusion signal decay in normal appearing white matter of multiple sclerosis. Magnetic resonance imaging, 31 (2). pp. 286-95. ISSN 1873-5894

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PURPOSE Our aim was to characterize bi-exponential diffusion signal changes in normal appearing white matter of multiple sclerosis (MS) patients. METHODS Diffusion parameters were measured using mono-exponential (0-1000 s/mm(2)) and bi-exponential (0-5000 s/mm(2)) approaches from 14 relapsing-remitting subtype of MS patients and 14 age- and sex-matched controls after acquiring diffusion-weighted images on a 3T MRI system. The results were analyzed using parametric or nonparametric tests and multiple linear regression models. RESULTS Mono-exponential apparent diffusion coefficient (ADC) slightly increased in controls (P=.09), but decreased significantly in MS as a function of age, nonetheless an elevated ADC was observed with increasing lesion number in patients. Bi-exponential analyses showed that the increased ADC is the result of decreased relative volume fraction of slow diffusing component (f(s)). However, the fast and slow diffusion components (ADC(f), ADC(s)) did not change as a function of either age in controls or lesion number and age in MS patients. CONCLUSIONS These data demonstrated that the myelin content of the white matter affects diffusion in relapsing-remitting subtype of multiple sclerosis that is possibly a consequence of the shift between different water fractions.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: Dr. Endre Czeiter
Date Deposited: 07 Feb 2014 18:31
Last Modified: 07 Feb 2014 18:31

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