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White-matter microstructure and language lateralization in left-handers: a whole-brain MRI analysis.

Perlaki, Gabor and Horvath, Reka and Orsi, Gergely and Aradi, Mihaly and Auer, Tibor and Varga, Eszter and Kantor, Gyongyi and Altbäcker, Anna and John, Flora and Doczi, Tamas and Komoly, Samuel and Kovacs, Norbert and Schwarcz, Attila and Janszky, Jozsef (2013) White-matter microstructure and language lateralization in left-handers: a whole-brain MRI analysis. Brain and cognition, 82 (3). pp. 319-328. ISSN 1090-2147

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Abstract

Most people are left-hemisphere dominant for language. However the neuroanatomy of language lateralization is not fully understood. By combining functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), we studied whether language lateralization is associated with cerebral white-matter (WM) microstructure. Sixteen healthy, left-handed women aged 20-25 were included in the study. Left-handers were targeted in order to increase the chances of involving subjects with atypical language lateralization. Language lateralization was determined by fMRI using a verbal fluency paradigm. Tract-based spatial statistics analysis of DTI data was applied to test for WM microstructural correlates of language lateralization across the whole brain. Fractional anisotropy and mean diffusivity were used as indicators of WM microstructural organization. Right-hemispheric language dominance was associated with reduced microstructural integrity of the left superior longitudinal fasciculus and left-sided parietal lobe WM. In left-handed women, reduced integrity of the left-sided language related tracts may be closely linked to the development of right hemispheric language dominance. Our results may offer new insights into language lateralization and structure-function relationships in human language system.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: Dr. Endre Czeiter
Date Deposited: 07 Feb 2014 17:24
Last Modified: 07 Feb 2014 17:24
URI: http://real.mtak.hu/id/eprint/10172

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