Changes in neuroplasticity following early-life social adversities

Miskolczi, Christina and Halász, József and Mikics, Éva (2019) Changes in neuroplasticity following early-life social adversities. PEDIATRIC RESEARCH, 85. pp. 225-233. ISSN 0031-3998

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Social adversities experienced in childhood can have a profound impact on the developing brain, leading to the emergence of psychopathologies in adulthood. Despite the burden this places on both the individual and society, the neurobiological aspects mediating this transition remain unclear. Recent advances in preclinical and clinical research have begun examining neuroplasticity-the nervous system's ability to form adaptive changes in response to new experience-in the context of early-life vulnerability to social adversities and plasticity-related alterations following such traumatic events. A key mediator of plasticity-related molecular processes is the brain-derived neurotrophic factor (BDNF), which has also been implicated in various psychiatric disorders related to childhood social adversities. Preclinical and clinical data suggest early-life social adversities (ELSA) might be associated with accelerated maturation of social network circuitry, a possible ontogenic adaptation to the adverse environment. Neural plasticity decreases by adulthood, lessening the efficacy of treatment in ELSA-related psychiatric disorders. However, literature data suggest that by increasing BDNF/TrkB signalling through antidepressant treatment a juvenile-like plasticity state can be induced, which allows for reorganization of the social circuitry when guided by psychotherapy and surrounded by a safe and positive environment.

Item Type: Article
Additional Information: Journal Article; Review Department of Behavioural Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest, Hungary Vadaskert Child and Adolescent Psychiatry Hospital, Budapest, Hungary Cited By :2 Export Date: 16 August 2019 CODEN: PEREB Correspondence Address: Mikics, É.; Department of Behavioural Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of SciencesHungary; email: Chemicals/CAS: brain derived neurotrophic factor, 218441-99-7 Funding details: 2017-1.2.1-NKP-2017-00002 Funding details: Hungarian Scientific Research Fund, K125390 Funding text 1: This study was supported by the Hungarian Scientific Research Fund (Grant No. K125390 (E.M.)) and the Hungarian Brain Research Programme (Grant No. 2017-1.2.1-NKP-2017-00002 (E.M.)).
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: MTMT SWORD
Date Deposited: 10 Oct 2019 13:12
Last Modified: 10 Oct 2019 13:12

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