Purinergic signaling in the organ of Corti: potential therapeutic targets of sensorineural hearing losses

Berekméri, Eszter and Szepesy, Judit and Köles, László and Zelles, Tibor (2019) Purinergic signaling in the organ of Corti: potential therapeutic targets of sensorineural hearing losses. BRAIN RESEARCH BULLETIN, 151. pp. 109-118. ISSN 0361-9230

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Purinergic signaling is deeply involved in the development, functions and protective mechanisms of the cochlea. Release of ATP and activation of purinergic receptors on sensory and supporting/epithelial cells play a substantial role in cochlear (patho)physiology. Both the ionotropic P2X and the metabotropic P2Y receptors are widely distributed on the inner and outer hair cells as well as on the different supporting cells in the organ of Corti and on other epithelial cells in the scala media. Among others, they are implicated in the sensitivity adjustment of the receptor cells by a K+ shunt and can attenuate the cochlear amplification by modifying cochlear micromechanics acting on outer hair cells and supporting cells. Cochlear blood flow is also regulated by purines. Sensorineural hearing losses currently lack any specific or efficient pharmacotherapy. Decreasing hearing sensitivity and increasing cochlear blood supply by pharmacological targeting of purinergic signaling in the cochlea are potential new therapeutic approaches in these hearing disabilities, especially in the noise-induced ones.

Item Type: Article
Uncontrolled Keywords: Purinergic signaling; Organ of Corti; Supporting cells; Hearing sensitivity; Sensorineural hearing losses; Noise induced hearing loss
Subjects: R Medicine / orvostudomány > RF Otorhinolaryngology / orr-, fül-, gégészet
R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan
Depositing User: MTMT SWORD
Date Deposited: 29 Oct 2019 09:10
Last Modified: 29 Oct 2019 09:10

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