Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer

Kang, M H and Jeong, K J and Kim, W Y and Lee, H J and Gong, G and Suh, N and Győrffy, Balázs and Kim, S and Jeong, S Y and Mills, G B and Park, Y-Y (2017) Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer. ONCOGENE, 36 (12). pp. 1745-1752. ISSN 0950-9232

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Official URL: https://doi.org/10.1038/onc.2016.327

Abstract

Musashi RNA-binding protein 2 (MSI2) has important roles in human cancer. However, the regulatory mechanisms by whichMSI2alters breast cancer pathophysiology have not been clearly identified. Here we demonstrate that MSI2 directly regulates estrogenreceptor 1 (ESR1), which is a well-known therapeutic target and has been shown to reflect clinical outcomes in breast cancer. Basedon gene expression data analysis, we found that MSI2 expression was highly enriched in estrogen receptor (ER)-positive breastcancer and that MSI2 expression was significantly correlated with ESR1 expression, including expression of ESR1 downstream targetgenes. In addition, MSI2 levels were associated with clinical outcomes. MSI2 influenced breast cancer cell growth by altering ESR1function. MSI2 alters ESR1 by binding specific sites in ESR1 RNA and by increasing ESR1 protein stability. Taken together, ourfindings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical relevance ofthe RNA-binding protein MSI2 in breast cancer.

Item Type:	Article
Additional Information:	Kang, M H és Jeong, K J és Kim, W Y és Lee, H J és Gong, G és Suh, N és Győrffy, Balázs és Kim, S és Jeong, S Y és Mills, G B és Park, Y-Y (2019) Correction. ONCOGENE, 38 (22). pp. 4427-4428. ISSN 0950-9232 DOI: https://doi.org/10.1038/s41388-019-0721-x The original version of this article contained error in Figure 2e. In Figure 2e, the 6th colony image of T47D cells treated with shMSI2 was inadvertently replaced with a duplicate of 7th colony image. However, the conclusions reported in the manuscript are not affected by figure replacement. The authors regret that these errors were made and apologize for the confusion and inconvenience. The correct version of this figure panel appears in the Author Correction associated with this Article.
Subjects:	R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia R Medicine / orvostudomány > RJ Pediatrics / gyermekgyógyászat
SWORD Depositor:	MTMT SWORD
Depositing User:	MTMT SWORD
Date Deposited:	28 Nov 2019 13:46
Last Modified:	28 Nov 2019 15:02
URI:	http://real.mtak.hu/id/eprint/103951

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