Oehme, Florian and Krahl S., Stefan and Győrffy, Balázs and Muessle, Benjamin and Rao, Venkatesh and Greif, Helena and Ziegle, Nicole and Lin, Kuailu and Thepkaysone, May-Linn and Polster, Heike and Tonn, Torsten and Schneider, Martin and Weitz, Juergen and Baenke, Franziska and Kahlert, Christoph (2019) Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer. RNA BIOLOGY, 16 (10). pp. 1339-1345. ISSN 1547-6286
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LowlevelofexosomallongnoncodingRNAHOTTIPisaprognosticbiomarkerincolorectalcancer.pdf Restricted to Repository staff only Download (2MB) | Request a copy |
Abstract
Molecular risk stratification of colorectal cancer can improve patient outcome. A panel of lncRNAs (H19, HOTTIP, HULC and MALAT1) derived from serum exosomes of patients with non-metastatic CRC and healthy donors was analyzed. Exosomes from healthy donors carried significantly more H19, HULC and HOTTIP transcripts in comparison to CRC patients. Correlation analysis between lncRNAs and clinical data revealed a statistical significance between low levels of exosomal HOTTIP and poor overall survival. This was confirmed by multivariate analysis that HOTTIP is an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69–11.98, p = 0.0027). Here, HOTTIP poses to be a valid biomarker for patients with a CRC to predict post-surgical survival time. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
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| Additional Information: | Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden, Dresden, Germany MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary Department of Pediatrics, Semmelweis University, Budapest, Hungary German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany Department for Transfusion Medicine, German Red Cross Blood Donation Service North-East, Dresden, Germany Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany Export Date: 25 September 2019 Correspondence Address: Kahlert, C.; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden, Fetscherstrasse 74, Germany; email: Christoph.Kahlert@uniklinikum-dresden.de Funding details: 5/15 Funding details: Deutsche Forschungsgemeinschaft, DFG, KA 3511/3–1, KH-129581 Funding text 1: This work was supported by the Deutsche Forschungsgemeinschaft [KA 3511/3–1]; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFIH) [NVKP_16–1–2016–0037]; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFIH) [KH-129581]; Roland Ernst Foundation [5/15]. Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden, Dresden, Germany MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary Department of Pediatrics, Semmelweis University, Budapest, Hungary German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany Department for Transfusion Medicine, German Red Cross Blood Donation Service North-East, Dresden, Germany Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany Export Date: 11 October 2019 Correspondence Address: Kahlert, C.; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden, Fetscherstrasse 74, Germany; email: Christoph.Kahlert@uniklinikum-dresden.de |
| Uncontrolled Keywords: | diagnosis; colorectal cancer; Exosomes; long non-coding RNA; liquid biopsy; |
| Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia R Medicine / orvostudomány > RJ Pediatrics / gyermekgyógyászat |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 28 Nov 2019 21:25 |
| Last Modified: | 28 Nov 2019 21:25 |
| URI: | http://real.mtak.hu/id/eprint/103960 |
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