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Stability study of nasal powder formulation containing nanosized lamotrigine

Gieszinger, Péter and Katona, Gábor and Révész, Piroska and Ambrus, Rita (2020) Stability study of nasal powder formulation containing nanosized lamotrigine. ACTA PHARMACEUTICA HUNGARICA, 90 (1). pp. 27-31. ISSN 0001-6659

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Abstract

Drug administration through the nose offers great possibilities which have been discovered in the past few decades. Besides the most known local effect, systemic and central nervous system effect is also available, the administration is non-painful and the degradation effect of the gastrointestinal tract can be avoided. Amongst the nasal formulations, powders have become more popular as their stability is favorable compared to the liquid formulations and a higher doses can be administered in powder form. The quality insurance and stability of the products in the pharmaceutical field have gained considerable attention in the last decades. Due to this fact, the aim was to execute a long-term stability study of a previously developed, nanosized lamotrigine (LAM) containing nasal powder (NP) formulation. The results of the stability test showed that the NP formulation preserved its key properties (particle size, morphology, structure and in vitro drug release) after 6 months of storage.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 29 Jul 2020 09:08
Last Modified: 29 Jul 2020 09:08
URI: http://real.mtak.hu/id/eprint/111791

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