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Analysis of Aristolochlic Acids and Evaluation of Antibacterial Activity of Aristolochia clematitis L.

Bartha, Gergely Sámuel and Tóth, Gergő and Horváth, Péter and Kiss, Eszter and Papp, Nóra and Kerényi, Mónika (2019) Analysis of Aristolochlic Acids and Evaluation of Antibacterial Activity of Aristolochia clematitis L. BIOLOGIA FUTURA, 70 (4). pp. 323-329. ISSN 2676-8615 (print); 2676-8607 (online)

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Abstract

Introduction: Several Aristolochia species were used as medicinal herb across Europe and in recent years, their antimicrobial activity has also been investigated. Materials and methods: In this study, A. clematitis was selected to evaluate the aristolochic acids I and II (AA I and AA II) concentrations and the antimicrobial activity of methanol, hexane, butanol, and ethyl acetate extracts of the root, stem, leaf, root, and fruit. AA I and AA II contents were measured by a validated high-performance liquid chromatography–ultraviolet method. Results: Each fraction of the plant contained AA I and AA II and the root was found to have the highest contents of AA I (1.09%) and AA II (0.7454%). The minimum inhibitory concentrations of all extracts were determined by standard microdilution method. The fruit’s extracts showed the most efficient antimicrobial effect against both methicillin sensitive and resistant Staphylococcus aureus strains. Conclusion: Correlation between the AA I and AA II concentrations and the antimicrobial effect was not found.

Item Type: Article
Uncontrolled Keywords: Aristolochia clematitis; HPLC; aristolochic acid; antimicrobial effect
Subjects: Q Science / természettudomány > QH Natural history / természetrajz
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 23 Sep 2020 11:16
Last Modified: 02 Nov 2021 16:30
URI: http://real.mtak.hu/id/eprint/114131

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