Kocsis, Tícia and Molnár, Bálint and Németh, Dávid and Hegyi, Péter and Szakács, Zsolt and Bálint, Alexandra and Garami, András and Soós, Alexandra and Márta, Katalin and Varjú-Solymár, Margit (2020) Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus : a meta-analysis of randomized clinical trials. SCIENTIFIC REPORTS, 10 (1). ISSN 2045-2322
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Abstract
Probiotics have been reported to have a positive impact on the metabolic control of patients with type 2 diabetes. We aimed to systematically evaluate the effects of probiotics on cardiometabolic parameters in type 2 diabetes based on randomized controlled studies. MEDLINE, Embase, and CENTRAL databases were reviewed to search for randomized controlled trials that examined the effects of probiotic supplementation on cardiometabolic parameters in patients with type 2 diabetes. 32 trials provided results suitable to be included in the analysis. The effects of probiotics were calculated for the following parameters: BMI, total cholesterol levels, LDL, triglycerides, HDL, CRP, HbA1c levels, fasting plasma glucose, fasting insulin levels, systolic and diastolic blood pressure values. Data analysis showed a significant effect of probiotics on reducing total cholesterol, triglyceride levels, CRP, HbA1c, fasting plasma glucose, fasting insulin levels, and both systolic and diastolic blood pressure values. Supplementation with probiotics increased HDL levels however did not have a significant effect on BMI or LDL levels. Our data clearly suggest that probiotics could be a supplementary therapeutic approach in type 2 diabetes mellitus patients to improve dyslipidemia and to promote better metabolic control. According to our analysis, probiotic supplementation is beneficial in type 2 diabetes mellitus.
| Item Type: | Article |
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| Additional Information: | Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti str., Pecs, 7624, Hungary Hungarian Academy of Sciences, University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary Szentágothai Research Center, University of Pécs, Pecs, Hungary Heart Institute, Medical School, University of Pécs, Pecs, Hungary Export Date: 27 July 2020 Correspondence Address: Solymár, M.; Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti str., Hungary; email: margit.solymar@aok.pte.hu Funding Agency and Grant Number: European Union (European Regional Development Fund)European Union (EU) [GINOP-2.3.2-15-2016-00048 - STAY ALIVE]; Human Resources Development Operational Programme Grant - European Union (European Regional Development Fund) [EFOP 3.6.2-16-2017-00006 - LIVE LONGER]; New National Excellence Program of the Hungarian Ministry of Human Capacities [UNKP-19-4-PTE-236] Funding text: This study was funded by "GINOP-2.3.2-15-2016-00048 - STAY ALIVE" co-financed by the European Union (European Regional Development Fund) within the framework of Programme Szechenyi 2020, and by the Human Resources Development Operational Programme Grant, Grant Number: EFOP 3.6.2-16-2017-00006 - LIVE LONGER which is co-financed by the European Union (European Regional Development Fund) within the framework of Programme Szechenyi 2020, and the New National Excellence Program of the Hungarian Ministry of Human Capacities (UNKP-19-4-PTE-236). |
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 24 Sep 2020 13:26 |
| Last Modified: | 24 Sep 2020 13:26 |
| URI: | http://real.mtak.hu/id/eprint/114453 |
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